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KMID : 1149120220190020065
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Journal of the Korean Society for Psoriasis
2022 Volume.19 No. 2 p.65 ~ p.68
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Psoriasis associated with dupilumab injections for atopic dermatitis: A case series
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Lee Yu-Jin
Kang Kyong-Won
Shin Min-Kyung
Lee June Hyun-Kyung
Choi Jae-Eun
Han Tae-Young
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Abstract
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The number of cases of psoriasis in patients receiving dupilumab injections for atopic dermatitis (AD) has increased significantly. It has been suggested that the use of dupilumab to block interleukin-4 activity induces psoriatic inflammation in AD patients. We report four patients with AD who received dupilumab injections and presented with new-onset psoriatic dermatitis during treatment. The average latency period of psoriasis onset after dupilumab initiation was 4.5 months. Biopsies from the patients showed typical characteristics of psoriasis. Topical corticosteroids and/or oral cyclosporin were used alongside dupilumab in three patients, and significant improvement was seen. The other patient started narrow- band ultraviolet B therapy, but there was no improvement; therefore, the patient’s dupilumab injections were temporarily discontinued. We report the possibility of de novo psoriasis in AD patients treated with dupilumab.
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KEYWORD
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Atopic dermatitis, Immune response, Psoriasis
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